Using the Moxy drug-coated balloon catheter in a coronary or peripheral intervention is very similar to using a regular angioplasty balloon. In Moxy clinical trials, procedure times have been short and technically straightforward.

Step 1: Vessel Preparation

After a standard guidewire is placed in the artery, standard balloon angioplasty may be performed to ensure a clear pathway for delivery of the Moxy balloon .

Step 2: Balloon Inflation

The Moxy balloon can be delivered through the sheath or guide catheter of the physician’s choice. A three-minute transit time window permits ample time for the physician to advance the balloon to the target lesion. Moxy is positioned across the entire length of the treatment area. The balloon should extend at least 5mm beyond the injury area on both sides.

Once Moxy is positioned across the entire length of the treatment area, it is inflated for a minimum of 30 seconds. The balloon releases the drug coating during this initial inflation. Inflation times are not restricted. If longer inflation times are needed due to lesion morphology, inflation times beyond 30 seconds will not increase the therapeutic drug dose to the vessel wall.

Step 3: Balloon Removal

The Moxy balloon catheter is deflated and retracted through the sheath or guide catheter. Paclitaxel and the drug carrier are left on the endoluminal surface and begin to absorb into the blood vessel wall.

Post-Procedure Biological Effect

Over time, therapeutic drug levels are sustained in the deeper layers of the arterial wall but not in the endothelium, thereby allowing new endothelial cells to grow and re-line the lumen. As a result, the drug continues to inhibit restenosis in deep cell layers after the lumen has been restored and re-endothelialized.